2-Cl-C.OXT-A stimulates contraction through the suppression of phosphodiesterase activity in human induced pluripotent stem cell-derived cardiac organoids

BACKGROUND: 2-Cl-C.OXT-A (COA-Cl) is a novel synthesized adenosine analog that activates Sphingosine-1-phosphate 1 receptor (S1P1R) and combines with the adenosine A1 receptor (A1R) in G proteins and was shown to enhance angiogenesis and improve the brain function in rat stroke models. However, the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kitsuka, Takahiro, Itoh, Manabu, Amamoto, Sojiro, Arai, Ken-ichi, Oyama, Junichi, Node, Koichi, Toda, Shuji, Morita, Shigeki, Nishida, Takahiro, Nakayama, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622471/
https://ncbi.nlm.nih.gov/pubmed/31295264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0213114
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