Mesangial Deposition Can Strongly Involve Innate-Like IgA Molecules Lacking Affinity Maturation

BACKGROUND: IgA nephropathy (IgAN) often follows infections and features IgA mesangial deposition. Polymeric IgA deposits in the mesangium seem to have varied pathogenic potential, but understanding their pathogenicity remains a challenge. Most mesangial IgA1 in human IgAN has a hypogalactosylated h...

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Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Wehbi, Batoul, Oblet, Christelle, Boyer, François, Huard, Arnaud, Druilhe, Anne, Paraf, François, Cogné, Etienne, Moreau, Jeanne, El Makhour, Yolla, Badran, Bassam, Van Egmond, Marjolein, Cogné, Michel, Aldigier, Jean-Claude
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2019
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622418/
https://ncbi.nlm.nih.gov/pubmed/31227634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018111089
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