Sulfatase 1 Promotes the Motor Neuron-to-Oligodendrocyte Fate Switch by Activating Shh Signaling in Olig2 Progenitors of the Embryonic Ventral Spinal Cord

In the developing ventral spinal cord, motor neurons (MNs) and oligodendrocyte precursor cells (OPCs) are sequentially generated from a common pool of neural progenitors included in the so-called pMN domain characterized by Olig2 expression. Here, we establish that the secreted Sulfatase 1 (Sulf1) i...

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Published in:J Neurosci
Main Authors: Touahri, Yacine, Escalas, Nathalie, Benazeraf, Bertrand, Cochard, Philippe, Danesin, Cathy, Soula, Cathy
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621745/
https://ncbi.nlm.nih.gov/pubmed/23238718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3553-12.2012
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