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Anoxia-Induced NMDA Receptor Activation Opens Pannexin Channels via Src Family Kinases

Anoxic depolarization of pyramidal neurons results from a large inward current that is activated, in part, by excessive glutamate release during exposure to anoxia/ischemia. Pannexin-1 (Panx1) channels can be activated both by ischemia and NMDA receptors (NMDARs), but the mechanisms of Panx1 activat...

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Vydáno v:J Neurosci
Hlavní autoři: Weilinger, Nicholas L., Tang, Peter L., Thompson, Roger J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621249/
https://ncbi.nlm.nih.gov/pubmed/22956847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1267-12.2012
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