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Toxic Role of K(+) Channel Oxidation in Mammalian Brain
Potassium (K(+)) channels are essential to neuronal signaling and survival. Here we show that these proteins are targets of reactive oxygen species in mammalian brain and that their oxidation contributes to neuropathy. Thus, the KCNB1 (Kv2.1) channel, which is abundantly expressed in cortex and hipp...
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| Publié dans: | J Neurosci |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6621216/ https://ncbi.nlm.nih.gov/pubmed/22442077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6153-11.2012 |
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