Gene therapy with apoptosis-associated speck-like protein, a newly described schwannoma tumor suppressor, inhibits schwannoma growth in vivo

BACKGROUND: We evaluated apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) as a schwannoma tumor suppressor and explored its utilization in a schwannoma gene therapy strategy that may be translated to clinical use. METHODS: ASC protein expression and mRNA level we...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Ahmed, Sherif G, Abdelnabi, Ahmed, Maguire, Casey A, Doha, Mohamed, Sagers, Jessica E, Lewis, Rebecca M, Muzikansky, Alona, Giovannini, Marco, Stemmer-Rachamimov, Anat, Stankovic, Konstantina M, Fulci, Giulia, Brenner, Gary J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620641/
https://ncbi.nlm.nih.gov/pubmed/30977509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz065
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