EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma

BACKGROUND: Posterior fossa A (PFA) ependymomas are one of 9 molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis, and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we repor...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Hübner, Jens-Martin, Müller, Torsten, Papageorgiou, Dimitris N, Mauermann, Monika, Krijgsveld, Jeroen, Russell, Robert B, Ellison, David W, Pfister, Stefan M, Pajtler, Kristian W, Kool, Marcel
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620627/
https://ncbi.nlm.nih.gov/pubmed/30923826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz058
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