Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion

Fibrosis is a common feature of chronic kidney disease; however, no clinical therapies effectively target the progression of fibrosis. Inhibition of fibronectin polymerization with the small peptide pUR4 attenuates fibrosis in the liver and heart. Here, we show that pUR4 decreases renal fibrosis and...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Bowers, Stephanie L. K., Davis-Rodriguez, Stephanie, Thomas, Zachary M., Rudomanova, Valeria, Bacon, W. Clark, Beiersdorfer, Alex, Ma, Qing, Devarajan, Prasad, Blaxall, Burns C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
Schlagworte:
Rapid Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620592/
https://ncbi.nlm.nih.gov/pubmed/31017009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00117.2019
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