Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insu...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Wang, Jinqiang, Yu, Jicheng, Zhang, Yuqi, Zhang, Xudong, Kahkoska, Anna R., Chen, Guojun, Wang, Zejun, Sun, Wujin, Cai, Lulu, Chen, Zhaowei, Qian, Chenggen, Shen, Qundong, Khademhosseini, Ali, Buse, John B., Gu, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620100/
https://ncbi.nlm.nih.gov/pubmed/31309150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw4357
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