Reducing GABA(A) α5 Receptor-Mediated Inhibition Rescues Functional and Neuromorphological Deficits in a Mouse Model of Down Syndrome

Down syndrome (DS) is associated with neurological complications, including cognitive deficits that lead to impairment in intellectual functioning. Increased GABA-mediated inhibition has been proposed as a mechanism underlying deficient cognition in the Ts65Dn (TS) mouse model of DS. We show that ch...

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Publicado no:J Neurosci
Main Authors: Martínez-Cué, Carmen, Martínez, Paula, Rueda, Noemí, Vidal, Rebeca, García, Susana, Vidal, Verónica, Corrales, Andrea, Montero, Juan A., Pazos, Ángel, Flórez, Jesús, Gasser, Rodolfo, Thomas, Andrew W., Honer, Michael, Knoflach, Frédéric, Trejo, Jose Luis, Wettstein, Joseph G., Hernández, Maria-Clemencia
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619314/
https://ncbi.nlm.nih.gov/pubmed/23447605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1203-12.2013
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