Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

Down syndrome (DS) phenotypes result from the overexpression of several dosage-sensitive genes. The DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene, which has been implicated in the behavioral and neuronal alterations that are characteristic of DS, plays a role in neu...

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Hauptverfasser: García-Cerro, Susana, Martínez, Paula, Vidal, Verónica, Corrales, Andrea, Flórez, Jesús, Vidal, Rebeca, Rueda, Noemí, Arbonés, María L., Martínez-Cué, Carmen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154723/
https://ncbi.nlm.nih.gov/pubmed/25188425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106572
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