Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation

The extracellular matrix (ECM) of the brain plays crucial roles during the development, maturation, and regeneration of the CNS. In a subpopulation of neurons, the ECM condenses to superstructures called perineuronal nets (PNNs) that surround synapses. Camillo Golgi described PNNs a century ago, yet...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Geissler, Maren, Gottschling, Christine, Aguado, Ainhara, Rauch, Uwe, Wetzel, Christian H., Hatt, Hanns, Faissner, Andreas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618965/
https://ncbi.nlm.nih.gov/pubmed/23637166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3275-12.2013
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