Knockdown of Prodynorphin Gene Prevents Cognitive Decline, Reduces Anxiety, and Rescues Loss of Group 1 Metabotropic Glutamate Receptor Function in Aging

Expression of dynorphin, an endogenous opioid peptide, increases with age and has been associated with memory impairments in rats. In human, prodynorphin (Pdyn) gene polymorphisms might be linked to cognitive function in the elderly. Moreover, elevated dynorphin levels have been reported in postmort...

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Argitaratua izan da:J Neurosci
Egile Nagusiak: Ménard, Caroline, Tse, Yiu Chung, Cavanagh, Chelsea, Chabot, Jean-Guy, Herzog, Herbert, Schwarzer, Christoph, Wong, Tak Pan, Quirion, Rémi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2013
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618545/
https://ncbi.nlm.nih.gov/pubmed/23904614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0290-13.2013
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