Knockdown of Prodynorphin Gene Prevents Cognitive Decline, Reduces Anxiety, and Rescues Loss of Group 1 Metabotropic Glutamate Receptor Function in Aging

Expression of dynorphin, an endogenous opioid peptide, increases with age and has been associated with memory impairments in rats. In human, prodynorphin (Pdyn) gene polymorphisms might be linked to cognitive function in the elderly. Moreover, elevated dynorphin levels have been reported in postmort...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ménard, Caroline, Tse, Yiu Chung, Cavanagh, Chelsea, Chabot, Jean-Guy, Herzog, Herbert, Schwarzer, Christoph, Wong, Tak Pan, Quirion, Rémi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618545/
https://ncbi.nlm.nih.gov/pubmed/23904614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0290-13.2013
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