Knockdown of Prodynorphin Gene Prevents Cognitive Decline, Reduces Anxiety, and Rescues Loss of Group 1 Metabotropic Glutamate Receptor Function in Aging

Expression of dynorphin, an endogenous opioid peptide, increases with age and has been associated with memory impairments in rats. In human, prodynorphin (Pdyn) gene polymorphisms might be linked to cognitive function in the elderly. Moreover, elevated dynorphin levels have been reported in postmort...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Ménard, Caroline, Tse, Yiu Chung, Cavanagh, Chelsea, Chabot, Jean-Guy, Herzog, Herbert, Schwarzer, Christoph, Wong, Tak Pan, Quirion, Rémi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618545/
https://ncbi.nlm.nih.gov/pubmed/23904614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0290-13.2013
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