The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling

Protein tyrosine phosphatase 1B (PTP1B) counteracts leptin signaling and is a therapeutic target for obesity and diabetes. Here we found that LIM domain only 4 (LMO4) inhibits PTP1B activity by increasing the oxidized inactive form of PTP1B. Mice with neuronal ablation of LMO4 have elevated PTP1B ac...

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Publicado no:J Neurosci
Main Authors: Pandey, Nihar R., Zhou, Xun, Qin, Zhaohong, Zaman, Tariq, Gomez-Smith, Mariana, Keyhanian, Kianoosh, Anisman, Hymie, Brunel, Jean Michel, Stewart, Alexandre F. R., Chen, Hsiao-Huei
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618542/
https://ncbi.nlm.nih.gov/pubmed/23904601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0746-13.2013
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