Protein kinase A‐mediated phosphorylation of naked cuticle homolog 2 stimulates cell‐surface delivery of transforming growth factor‐α for epidermal growth factor receptor transactivation

The classic mode of G protein‐coupled receptor (GPCR)‐mediated transactivation of the receptor tyrosine kinase epidermal growth factor receptor (EGFR) transactivation occurs via matrix metalloprotease (MMP)‐mediated cleavage of plasma membrane‐anchored EGFR ligands. Herein, we show that the Gαs‐acti...

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Veröffentlicht in:Traffic
Hauptverfasser: Cao, Zheng, Singh, Bhuminder, Li, Cunxi, Markham, Nicholas O., Carrington, Léolène J., Franklin, Jeffrey L., Graves‐Deal, Ramona, Kennedy, Eileen J., Goldenring, James R., Coffey, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons A/S 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618044/
https://ncbi.nlm.nih.gov/pubmed/30941853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12642
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