Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions

Characterization of tumors utilizing next‐generation sequencing methods, including assessment of the number of somatic mutations (tumor mutational burden [TMB]), is currently at the forefront of the field of personalized medicine. Recent clinical studies have associated high TMB with improved patien...

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Veröffentlicht in:Genes Chromosomes Cancer
Hauptverfasser: Stenzinger, Albrecht, Allen, Jeffrey D., Maas, Jörg, Stewart, Mark D., Merino, Diana M., Wempe, Madison M., Dietel, Manfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618007/
https://ncbi.nlm.nih.gov/pubmed/30664300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22733
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