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Metabolic requirements of human pro-inflammatory B cells in aging and obesity

The subset of pro-inflammatory B cells, called late memory, tissue-like or double negative (DN), accumulates in the blood of elderly individuals. Here we show that DN B cells do not proliferate and do not make antibodies to influenza antigens, but they secrete antibodies with autoimmune reactivity,...

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Veröffentlicht in:PLoS One
Hauptverfasser: Frasca, Daniela, Diaz, Alain, Romero, Maria, Thaller, Seth, Blomberg, Bonnie B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615614/
https://ncbi.nlm.nih.gov/pubmed/31287846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219545
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