Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options

BACKGROUND: Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at inhibiting chronic ethanol and nicotine self-administration and relapse by the n...

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Foilsithe in:Stem Cell Res Ther
Main Authors: Quintanilla, María Elena, Ezquer, Fernando, Morales, Paola, Santapau, Daniela, Berríos-Cárcamo, Pablo, Ezquer, Marcelo, Herrera-Marschitz, Mario, Israel, Yedy
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2019
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615104/
https://ncbi.nlm.nih.gov/pubmed/31286996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1304-z
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