Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia

Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global PA, we investigated the neuroprotective effect of intranasally administered s...

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Udgivet i:Int J Mol Sci
Main Authors: Farfán, Nancy, Carril, Jaime, Redel, Martina, Zamorano, Marta, Araya, Maureen, Monzón, Estephania, Alvarado, Raúl, Contreras, Norton, Tapia-Bustos, Andrea, Quintanilla, María Elena, Ezquer, Fernando, Valdés, José Luis, Israel, Yedy, Herrera-Marschitz, Mario, Morales, Paola
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589575/
https://ncbi.nlm.nih.gov/pubmed/33096871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207800
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