ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation

In our aging society, age-related hearing loss (ARHL) has become a major socioeconomic issue. Reactive oxygen species (ROS) may be one of the main causal factors of age-related cochlear cell degeneration. We examined whether ROS-induced DNA damage response drives cochlear cell senescence and contrib...

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Sparad:
Bibliografiska uppgifter
I publikationen:Mol Neurobiol
Huvudupphovsmän: Benkafadar, Nesrine, François, Florence, Affortit, Corentin, Casas, François, Ceccato, Jean-Charles, Menardo, Julien, Venail, Frederic, Malfroy-Camine, Bernard, Puel, Jean-Luc, Wang, Jing
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer US 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614136/
https://ncbi.nlm.nih.gov/pubmed/30693443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-1493-6
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