Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy
Abstract Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin‐induced ototoxicity remains unclear, and hearing preservation during cisplatin‐based chemotherapy in patients is lacking. We found activation of the ATM‐Chk2‐p53...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Nature
2016-10-01
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| Series: | EMBO Molecular Medicine |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.15252/emmm.201606230 |
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