Morphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome

Prolonged exposure to opioids results in analgesic tolerance, drug overdose, and death. The mechanism underlying morphine analgesic tolerance still remains unresolved. We show that morphine analgesic tolerance was significantly attenuated in germfree (GF) and in pan-antibiotic−treated mice. Reconsti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Li, Meng, Jingjing, Ban, Yuguang, Jalodia, Richa, Chupikova, Irina, Fernandez, Irina, Brito, Nivis, Sharma, Umakant, Abreu, Maria T., Ramakrishnan, Sundaram, Roy, Sabita
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613141/
https://ncbi.nlm.nih.gov/pubmed/31209039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901182116
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