MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation

IgA is the most abundantly produced antibody in the body and plays a crucial role in gut homeostasis and mucosal immunity. IgA forms a dimer that covalently associates with the joining (J) chain, which is essential for IgA transport into the mucosa. Here, we demonstrate that the marginal zone B and...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Xiong, Ermeng, Li, Yingqian, Min, Qing, Cui, Chaoqun, Liu, Jun, Hong, Rongjian, Lai, Nannan, Wang, Ying, Sun, Jiping, Matsumoto, Ryohtaroh, Takahashi, Daisuke, Hase, Koji, Shinkura, Reiko, Tsubata, Takeshi, Wang, Ji-Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613140/
https://ncbi.nlm.nih.gov/pubmed/31127044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904204116
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