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Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses

IgM antibodies have been known for decades to enhance humoral immune responses in an antigen-specific fashion. This enhancement has been thought to be dependent on complement activation by IgM–antigen complexes; however, recent genetic studies render this mechanism unlikely. Here, we describe a like...

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Detalhes bibliográficos
Main Authors: Ouchida, Rika, Mori, Hiromi, Hase, Koji, Takatsu, Hiroyuki, Kurosaki, Tomohiro, Tokuhisa, Takeshi, Ohno, Hiroshi, Wang, Ji-Yang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479561/
https://ncbi.nlm.nih.gov/pubmed/22988094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210706109
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