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Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

As bacterial resistance to traditional antibiotics continues to emerge, new alternatives are urgently needed. Antimicrobial peptides (AMPs) are important candidates. However, how AMPs are designed with in vivo efficacy is poorly understood. Our study was designed to understand structural moieties of...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Mishra, Biswajit, Lakshmaiah Narayana, Jayaram, Lushnikova, Tamara, Wang, Xiuqing, Wang, Guangshun
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613076/
https://ncbi.nlm.nih.gov/pubmed/31209048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821410116
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