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GkmExplain: fast and accurate interpretation of nonlinear gapped k-mer SVMs

SUMMARY: Support Vector Machines with gapped k-mer kernels (gkm-SVMs) have been used to learn predictive models of regulatory DNA sequence. However, interpreting predictive sequence patterns learned by gkm-SVMs can be challenging. Existing interpretation methods such as deltaSVM, in-silico mutagenes...

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Bibliographic Details
Published in:Bioinformatics
Main Authors: Shrikumar, Avanti, Prakash, Eva, Kundaje, Anshul
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612808/
https://ncbi.nlm.nih.gov/pubmed/31510661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz322
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