Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation

With reduced thymic activity, the population of naïve T cells in humans is maintained by homeostatic proliferation throughout adult life. In young adults, naïve CD4 T cells have enormous proliferative potential and plasticity to differentiate into different lineages. Here, we explored whether naïve...

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Bibliografske podrobnosti
izdano v:Aging Cell
Main Authors: Hu, Bin, Li, Guangjin, Ye, Zhongde, Gustafson, Claire E., Tian, Lu, Weyand, Cornelia M., Goronzy, Jörg J.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612640/
https://ncbi.nlm.nih.gov/pubmed/31264370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12957
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