Transcriptomic analysis of human IL‐7 receptor alpha( low) and( high) effector memory CD8(+) T cells reveals an age‐associated signature linked to influenza vaccine response in older adults

Here, we investigated the relationship of the age‐associated expansion of IL‐7 receptor alpha low (IL‐7Rα(low)) effector memory (EM) CD8(+) T cells with the global transcriptomic profile of peripheral blood cells in humans. We found 231 aging signature genes of IL‐7Rα(low) EM CD8(+ )T cells that cor...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging Cell
Prif Awduron: Park, Hong‐Jai, Shin, Min Sun, Kim, Minhyung, Bilsborrow, Joshua B., Mohanty, Subhasis, Montgomery, Ruth R., Shaw, Albert C., You, Sungyong, Kang, Insoo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612637/
https://ncbi.nlm.nih.gov/pubmed/31044512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12960
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