Biodistribution and radiation dosimetry of the novel hypoxia PET probe [(18)F]DiFA and comparison with [(18)F]FMISO

BACKGROUND: To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[(18)F]-fluoropropyl)-2-nitroimidazole ([(18)F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity and efficient radiosynthesis. Here, we evaluated the radiation dosage, b...

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Publicat a:EJNMMI Res
Autors principals: Watanabe, Shiro, Shiga, Tohru, Hirata, Kenji, Magota, Keiichi, Okamoto, Shozo, Toyonaga, Takuya, Higashikawa, Kei, Yasui, Hironobu, Kobayashi, Jun, Nishijima, Ken-ichi, Iseki, Ken, Matsumoto, Hiroki, Kuge, Yuji, Tamaki, Nagara
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2019
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611855/
https://ncbi.nlm.nih.gov/pubmed/31278504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-019-0525-6
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