Lataa...

Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

Activated hepatic stellate cell (aHSC)-mediated liver fibrosis is essential to the development of liver metastasis. Here, we discover intra-hepatic scale-up of relaxin (RLN, an anti-fibrotic peptide) in response to fibrosis along with the upregulation of its primary receptor (RXFP1) on aHSCs. The el...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Hu, Mengying, Wang, Ying, Xu, Ligeng, An, Sai, Tang, Yu, Zhou, Xuefei, Li, Jingjing, Liu, Rihe, Huang, Leaf
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611764/
https://ncbi.nlm.nih.gov/pubmed/31278269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10893-8
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!