Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

Activated hepatic stellate cell (aHSC)-mediated liver fibrosis is essential to the development of liver metastasis. Here, we discover intra-hepatic scale-up of relaxin (RLN, an anti-fibrotic peptide) in response to fibrosis along with the upregulation of its primary receptor (RXFP1) on aHSCs. The el...

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Udgivet i:Nat Commun
Main Authors: Hu, Mengying, Wang, Ying, Xu, Ligeng, An, Sai, Tang, Yu, Zhou, Xuefei, Li, Jingjing, Liu, Rihe, Huang, Leaf
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611764/
https://ncbi.nlm.nih.gov/pubmed/31278269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10893-8
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