Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors

CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the development of biologics that inhibit SIRPα engagem...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Miller, Thomas W., Amason, Joshua D., Garcin, Elsa D., Lamy, Laurence, Dranchak, Patricia K., Macarthur, Ryan, Braisted, John, Rubin, Jeffrey S., Burgess, Teresa L., Farrell, Catherine L., Roberts, David D., Inglese, James
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611588/
https://ncbi.nlm.nih.gov/pubmed/31276567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218897
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