The Impact of Mevastatin on HCV Replication and Autophagy of Non-Transformed HCV Replicon Hepatocytes Is Influenced by the Extracellular Lipid Uptake

Statins efficiently inhibit cholesterol synthesis by blocking 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the mevalonate pathway. However, the effect of statins on intracellular cholesterol is partially counterbalanced by a consequent increased uptake of extracellular lipid sources. Hepatitis...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Vescovo, Tiziana, Refolo, Giulia, Manuelli, Matteo Ciancio, Tisone, Giuseppe, Piacentini, Mauro, Fimia, Gian Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611414/
https://ncbi.nlm.nih.gov/pubmed/31316383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00718
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