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The Impact of Mevastatin on HCV Replication and Autophagy of Non-Transformed HCV Replicon Hepatocytes Is Influenced by the Extracellular Lipid Uptake

Statins efficiently inhibit cholesterol synthesis by blocking 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the mevalonate pathway. However, the effect of statins on intracellular cholesterol is partially counterbalanced by a consequent increased uptake of extracellular lipid sources. Hepatitis...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Front Pharmacol
Κύριοι συγγραφείς: Vescovo, Tiziana, Refolo, Giulia, Manuelli, Matteo Ciancio, Tisone, Giuseppe, Piacentini, Mauro, Fimia, Gian Maria
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Frontiers Media S.A. 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611414/
https://ncbi.nlm.nih.gov/pubmed/31316383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00718
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