A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT(4)R) Agonist and Serotonergic Subtype 6 Receptor (5-HT(6)R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

This work describes the conception, synthesis, in vitro and in vivo biological evaluation of novel Multi-Target Directed Ligands (MTDL) able to both activate 5-HT(4) receptors, block 5-HT(6) receptors and inhibit acetylcholinesterase activity (AChE), in order to exert a synergistic anti-amnesic effe...

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Dettagli Bibliografici
Pubblicato in:Front Aging Neurosci
Autori principali: Hatat, Bérénice, Yahiaoui, Samir, Lecoutey, Cédric, Davis, Audrey, Freret, Thomas, Boulouard, Michel, Claeysen, Sylvie, Rochais, Christophe, Dallemagne, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611404/
https://ncbi.nlm.nih.gov/pubmed/31316368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00148
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