Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial

BACKGROUND: Lacunar stroke, a frequent clinical manifestation of small vessel disease (SVD), differs pathologically from other ischaemic stroke subtypes and has no specific long-term secondary prevention. Licenced drugs, isosorbide mononitrate (ISMN) and cilostazol, have relevant actions to prevent...

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Publicado en:EClinicalMedicine
Autores principales: Blair, Gordon W., Appleton, Jason P., Flaherty, Katie, Doubal, Fergus, Sprigg, Nikola, Dooley, Richard, Richardson, Carla, Hamilton, Iona, Law, Zhe Kang, Shi, Yulu, Stringer, Michael S., Thrippleton, Michael J., Boyd, Julia, Shuler, Kirsten, Bath, Philip M., Wardlaw, Joanna M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611094/
https://ncbi.nlm.nih.gov/pubmed/31317131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eclinm.2019.04.001
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