Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

Autophagy is required in diverse paradigms of lifespan extension, leading to the prevailing notion that autophagy is beneficial for longevity. However, why autophagy is harmful in certain contexts, remains unexplained. Here we show that mitochondrial permeability defines the impact of autophagy on a...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Zhou, Ben, Kreuzer, Johannes, Kumsta, Caroline, Wu, Lianfeng, Kamer, Kimberli J., Cedillo, Lucydalila, Zhang, Yuyao, Li, Sainan, Kacergis, Michael C., Webster, Christopher M., Fejes-Toth, Geza, Naray-Fejes-Toth, Aniko, Das, Sudeshna, Hansen, Malene, Haas, Wilhelm, Soukas, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610881/
https://ncbi.nlm.nih.gov/pubmed/30929899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.02.013
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