Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

Autophagy is required in diverse paradigms of lifespan extension, leading to the prevailing notion that autophagy is beneficial for longevity. However, why autophagy is harmful in certain contexts, remains unexplained. Here we show that mitochondrial permeability defines the impact of autophagy on a...

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Pubblicato in:Cell
Autori principali: Zhou, Ben, Kreuzer, Johannes, Kumsta, Caroline, Wu, Lianfeng, Kamer, Kimberli J., Cedillo, Lucydalila, Zhang, Yuyao, Li, Sainan, Kacergis, Michael C., Webster, Christopher M., Fejes-Toth, Geza, Naray-Fejes-Toth, Aniko, Das, Sudeshna, Hansen, Malene, Haas, Wilhelm, Soukas, Alexander A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610881/
https://ncbi.nlm.nih.gov/pubmed/30929899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.02.013
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