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The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na(+) transport

WNK1 belongs to a unique family of Ser/Thr kinases that have been implicated in the control of blood pressure. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. How overexpression...

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Bibliografiska uppgifter
Huvudupphovsmän: Náray-Fejes-Tóth, Anikó, Snyder, Peter M., Fejes-Tóth, Géza
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2004
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC536044/
https://ncbi.nlm.nih.gov/pubmed/15583131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408146101
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