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The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na(+) transport
WNK1 belongs to a unique family of Ser/Thr kinases that have been implicated in the control of blood pressure. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. How overexpression...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC536044/ https://ncbi.nlm.nih.gov/pubmed/15583131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408146101 |
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