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The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na(+) transport
WNK1 belongs to a unique family of Ser/Thr kinases that have been implicated in the control of blood pressure. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. How overexpression...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2004
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC536044/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15583131/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408146101 |
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