A B cell-specific enhancer orchestrates nuclear architecture to generate a diverse antigen receptor repertoire

The genome is organized into topologically associated domains (TAD) that enclose smaller subTADs. Here we identify and characterize an enhancer that is located in the middle of the V gene region of the immunoglobulin kappa light chain (Igκ) locus that becomes active preceding the stage at which this...

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Vydáno v:Mol Cell
Hlavní autoři: Barajas-Mora, E. Mauricio, Kleiman, Eden, Xu, Jeffrey, Carrico, Nancy C., Lu, Hanbin, Oltz, Eugene M., Murre, Cornelis, Feeney, Ann J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610861/
https://ncbi.nlm.nih.gov/pubmed/30449725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.10.013
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