Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias

Ectopic foci from pulmonary veins (PVs) comprise the main trigger associated with the initiation of atrial fibrillation (AF). An abrupt anatomical narrow-to-wide transition, modeled as in vitro geometrical patterning with similar configuration in the present study, is located at the junction of PVs...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Nakanishi, Hiroyuki, Lee, Jong-Kook, Miwa, Keiko, Masuyama, Kiyoshi, Yasutake, Hideki, Li, Jun, Tomoyama, Satoki, Honda, Yayoi, Deguchi, Jiro, Tsujimoto, Shinji, Hidaka, Kyoko, Miyagawa, Shigeru, Sawa, Yoshiki, Komuro, Issei, Sakata, Yasushi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610482/
https://ncbi.nlm.nih.gov/pubmed/31316396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00818
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