Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity

CANTOS (Canakinumab Antiinflammatory Thrombosis Outcome Study) confirmed interleukin (IL)–1β as an appealing therapeutic target for human atherosclerosis and related complications. However, there are serious gaps in our understanding of IL-1 production in atherosclerosis. Herein the authors show tha...

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Bibliographische Detailangaben
Veröffentlicht in:JACC Basic Transl Sci
Hauptverfasser: Jiang, Xintong, Wang, Feilong, Wang, Yajuan, Gisterå, Anton, Roy, Joy, Paulsson-Berne, Gabrielle, Hedin, Ulf, Lerman, Amir, Hansson, Göran K., Herrmann, Joerg, Yan, Zhong-qun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
CLINICAL RESEARCH
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610158/
https://ncbi.nlm.nih.gov/pubmed/31312755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.02.007
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