Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis

Increased platelet activity occurs in type 2 diabetes mellitus (T2DM) and such platelet dysregulation likely originates from altered megakaryopoiesis. We initiated identification of dysregulated pathways in megakaryocytes in the setting of T2DM. We evaluated through transcriptomic analysis, differen...

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Published in:Sci Rep
Main Authors: Mezzapesa, Anna, Bastelica, Delphine, Crescence, Lydie, Poggi, Marjorie, Grino, Michel, Peiretti, Franck, Panicot-Dubois, Laurence, Dupont, Annabelle, Valero, René, Maraninchi, Marie, Bordet, Jean-Claude, Alessi, Marie-Christine, Dubois, Christophe, Canault, Matthias
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610149/
https://ncbi.nlm.nih.gov/pubmed/31270351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45805-9
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