Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory

The impairment of learning and memory is a well-documented effect of both natural and synthetic cannabinoids. In the present study, we aimed to investigate the effect of acute administration of JWH-018, a synthetic cannabinoid, on the hippocampal metabolome to assess biochemical changes in vivo. JWH...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Ren-shi, Fukumori, Ryo, Takeda, Tomoki, Song, Yingxia, Morimoto, Satoshi, Kikura-Hanajiri, Ruri, Yamaguchi, Taku, Watanabe, Kazuhito, Aritake, Kousuke, Tanaka, Yoshitaka, Yamada, Hideyuki, Yamamoto, Tsuneyuki, Ishii, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610139/
https://ncbi.nlm.nih.gov/pubmed/31270353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45969-4
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