Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization

Our recent study demonstrated that cancer cells with compromised glutathione homeostasis, including reduced expression of the glutathione reductase (GSR) gene, were selectively killed by inhibition of thioredoxin reductase. The human GSR gene is located on chromosome 8p, a region often lost in lung...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Baity, Mohamed, Wang, Li, Correa, Arlene M, Zhang, Xiaoshan, Zhang, Ran, Pataer, Apar, Wu, Shuhong, Meng, Qing H, Antonoff, Mara B, Hofstetter, Wayne L, Mehran, Reza J, Rice, David C, Roth, Jack A, Sepesi, Boris, Swisher, Stephen G, Vaporciyan, Ara A, Walsh, Garrett L, Zhao, Ming, Gu, Jun, Fang, Bingliang
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2019
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610060/
https://ncbi.nlm.nih.gov/pubmed/31285952
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