Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization

Our recent study demonstrated that cancer cells with compromised glutathione homeostasis, including reduced expression of the glutathione reductase (GSR) gene, were selectively killed by inhibition of thioredoxin reductase. The human GSR gene is located on chromosome 8p, a region often lost in lung...

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Bibliographic Details
Published in:Am J Cancer Res
Main Authors: Baity, Mohamed, Wang, Li, Correa, Arlene M, Zhang, Xiaoshan, Zhang, Ran, Pataer, Apar, Wu, Shuhong, Meng, Qing H, Antonoff, Mara B, Hofstetter, Wayne L, Mehran, Reza J, Rice, David C, Roth, Jack A, Sepesi, Boris, Swisher, Stephen G, Vaporciyan, Ara A, Walsh, Garrett L, Zhao, Ming, Gu, Jun, Fang, Bingliang
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2019
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610060/
https://ncbi.nlm.nih.gov/pubmed/31285952
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