Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice

Skeletal muscle wasting is a feature of cancer cachexia that increases patient morbidity and mortality. Matrine, the main bioactive component of Sophora flavescens, has been approved for the prevention and therapy of cancer cachexia in China. However, to the best of our knowledge, its mechanism in i...

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Detalhes bibliográficos
Publicado no:Oncol Rep
Main Authors: Chen, Li, Chen, Linlin, Wan, Lili, Huo, Yan, Huang, Jinlu, Li, Jie, Lu, Jin, Xin, Bo, Yang, Quanjun, Guo, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610044/
https://ncbi.nlm.nih.gov/pubmed/31233199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2019.7205
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