Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes

Type 1 diabetes (T1D) involves the interaction of multiple gene variants, environmental factors, and immunoregulatory dysfunction. Major T1D genetic risk loci encode HLA-DR and -DQ. Genetic heterogeneity and linkage disequilibrium in the highly polymorphic HLA region confound attempts to identify ad...

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Detaylı Bibliyografya
Yayımlandı:Diabetes
Asıl Yazarlar: Aydemir, Özkan, Noble, Janelle A., Bailey, Jeffrey A., Lernmark, Åke, Marsh, Patrick, Andersson Svärd, Agnes, Bearoff, Frank, Blankenhorn, Elizabeth P., Mordes, John P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Diabetes Association 2019
Konular:
Genetics/Genomes/Proteomics/Metabolomics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609989/
https://ncbi.nlm.nih.gov/pubmed/30962219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-1128
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