Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2‐deficient cells, we screened a chemical library containing compounds in clinica...

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Gepubliceerd in:EMBO Mol Med
Hoofdauteurs: Tacconi, Eliana MC, Badie, Sophie, De Gregoriis, Giuliana, Reisländer, Timo, Lai, Xianning, Porru, Manuela, Folio, Cecilia, Moore, John, Kopp, Arnaud, Baguña Torres, Júlia, Sneddon, Deborah, Green, Marcus, Dedic, Simon, Lee, Jonathan W, Batra, Ankita Sati, Rueda, Oscar M, Bruna, Alejandra, Leonetti, Carlo, Caldas, Carlos, Cornelissen, Bart, Brino, Laurent, Ryan, Anderson, Biroccio, Annamaria, Tarsounas, Madalena
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609913/
https://ncbi.nlm.nih.gov/pubmed/31273933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809982
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