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Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
RNAi-based bone anabolic gene therapy has demonstrated initial success, but many practical challenges are still unmet. Here, we demonstrate that a recombinant adeno-associated virus 9 (rAAV9) is highly effective for transducing osteoblast lineage cells in the bone. The adaptor protein Schnurri-3 (SH...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6609711/ https://ncbi.nlm.nih.gov/pubmed/31273195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10809-6 |
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